The Food Additive tBHQ Impairs NK Cell Cytotoxicity Against Influenza Infection (FS12-02-19)

Swift and Strong NK Cell Responses Protect 129 Mice against High-Dose Influenza Virus Infection.

It is generally unclear what roles NK cells play during influenza virus infection with regard to different host genetic backgrounds. In this study, we show that in six inbred mouse strains, NK cells play an important protective role only in 129 mice during high-dose influenza A H1N1 virus infection. Swift and strong NK cell responses efficiently control early pulmonary viral replication in 129 ...

Is COVID-19 Infection Transmitted Through Food?

 Coronavirus disease (COVID) has had a growing outbreak around the world. China reported COVID-19 infection for the first time in December 2019. Symptoms of this disease often include respiratory symptoms, but gastrointestinal symptoms (nausea, vomiting, and diarrhea) were also reported in COVID-19 infection. Coronavirus transmits through direct droplets, contact, or fomites. However, other mod...

Regulation of NK Cell-Mediated Cytotoxicity

Type I IFN promotes NK cell expansion during viral infection by protecting NK cells against fratricide

Type I interferon (IFN) is crucial in host antiviral defense. Previous studies have described the pleiotropic role of type I IFNs on innate and adaptive immune cells during viral infection. Here, we demonstrate that natural killer (NK) cells from mice lacking the type I IFN-α receptor (Ifnar(-/-)) or STAT1 (which signals downstream of IFNAR) are defective in expansion and memory cell formation ...

P24. Aviscumine enhances NK- cytotoxicity against tumor cells

Background The mistletoe lectin I belongs to a new class of anticancer drugs with type II ribosomal inhibitor activity. The recombinant mistletoe lectin (aviscumine) has shown immunomodulatory and cytotoxic activity in preclinical models as well as potential antitumor effects in phase I and I/II clinical trials. The aim of this study was to further elucidate the immunostimulatory capacity of av...